Test-and-Treat Strategies forHelicobacter pyloriin Uninvestigated Dyspepsia: A Canadian Economic Anaylsis Academic Article uri icon

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abstract

  • BACKGROUND: Recognition of the pivotal role ofHelicobacter pyloriin the pathogenesis of peptic ulcer disease has revolutionized primary care approaches to dyspepsia. Decision analysis was used to compare the cost effectiveness of empirical ranitidine with a test and treat strategy using eitherH pyloriserology or the13carbon-urea breath test (13C-UBT).PATIENTS AND METHODS: A cohort of patients under age 50 years presenting with uninvestigated dyspepsia was evaluated. Three initial strategies were compared with respect to direct medical costs and effectiveness in curingH pylori-related ulcers - empirical ranitidine,H pyloriserology and UBT. A one-year time horizon and third-party payer perspective were adopted in a Canadian health care setting.RESULTS: UBT was more costly than either serology or ranitidine but was the most effective strategy and required the fewest endoscopies. No strategy demonstrated dominance over another in the base case. The incremental cost effectiveness ratio (ICER) of serology versus ranitidine was $118/cure, and sensitivity analysis induced dominance of serology in several plausible scenarios. The baseline ICER of UBT versus serology was $885/cure but showed substantial variation in sensitivity analysis. Each ICER was highly sensitive to variation in the cost of the tests themselves. At a serology cost of $25, UBT became dominant when its cost fell to $39.CONCLUSIONS: In low risk patients with uninvestigated dyspepsia, testing forH pyloriusing serology appears to be economically attractive.13C-UBT may be a cost effective alternative to serology if local conditions closely approximate the model parameters. Future changes in the costs of serology and13C-UBT may determine the optimal approach.

publication date

  • 2000