Journal article
Association between high expression macrophage migration inhibitory factor (MIF) alleles and West Nile virus encephalitis
Abstract
Infection with mosquito-borne West Nile virus (WNV) is usually asymptomatic but can lead to severe WNV encephalitis. The innate cytokine, macrophage migration inhibitory factor (MIF), is elevated in patients with WNV encephalitis and promotes viral neuroinvasion and mortality in animal models. In a case-control study, we examined functional polymorphisms in the MIF locus in a cohort of 454 North American patients with neuroinvasive WNV disease …
Authors
Das R; Loughran K; Murchison C; Qian F; Leng L; Song Y; Montgomery RR; Loeb M; Bucala R
Journal
Cytokine, Vol. 78, , pp. 51–54
Publisher
Elsevier
Publication Date
February 2016
DOI
10.1016/j.cyto.2015.11.021
ISSN
1043-4666