Journal article
In vivo and in vitro Validation of Reference Tissue Models for the mGluR5 Ligand [11C]ABP688
Abstract
The primary objective of this study was to verify the suitability of reference tissue-based quantification methods of the metabotropic glutamate receptor type 5 (mGluR(5)) with [(11)C]ABP688. This study presents in vivo (Positron Emission Tomography (PET)) and in vitro (autoradiography) measurements of mGluR(5) densities in the same rats and evaluates both noninvasive and blood-dependent pharmacokinetic models for the quantification of …
Authors
Elmenhorst D; Minuzzi L; Aliaga A; Rowley J; Massarweh G; Diksic M; Bauer A; Rosa-Neto P
Journal
Cerebrovascular and Brain Metabolism Reviews, Vol. 30, No. 8, pp. 1538–1549
Publisher
SAGE Publications
Publication Date
August 2010
DOI
10.1038/jcbfm.2010.65
ISSN
1040-8827