A Multicentre Trial of the Effectiveness of ζ Globin Enzyme Linked Immunosorbent Assay (ELISA) and Hb H Inclusion Body Screening for the Detection of α Thalassemia Trait.

Abstract The most serious form of α thalassemia, Hb Barts hydrops fetalis, results in fetal death and dangerous obstetric complications. Syndromes containing two α gene deletions on the same chromosome (in cis), e.g. α thalassemia trait and Hb H disease, are carriers of this condition. The most common cis deletion is the Southeast Asian (--SEA/) deletion. The gold standard diagnosis for carriers is DNA investigation, a …