Journal article
IL-25 and IL-33 induce Type 2 inflammation in basophils from subjects with allergic asthma
Abstract
BackgroundThe alarmin cytokines IL-25 and IL-33 are key promoters of type 2 inflammation. Basophils respond to alarmin cytokines, however the relationship of these cytokines with basophil activation and recruitment in human studies of allergic asthma has not been well characterized. This study investigated the effect of IL-25 and IL-33 on basophils in a model of allergic asthma.Methods10 mild allergic asthmatics underwent allergen and diluent …
Authors
Salter BM; Oliveria JP; Nusca G; Smith SG; Tworek D; Mitchell PD; Watson RM; Sehmi R; Gauvreau GM
Journal
Respiratory Research, Vol. 17, No. 1,
Publisher
Springer Nature
Publication Date
December 2016
DOI
10.1186/s12931-016-0321-z
ISSN
1465-9921