Pancreatic Enzyme Activity in Obese and Lean Zucker Rats: A Developmental Study

Exocrine pancreatic enzyme activities were measured in female, obese and lean Zucker rats at 1, 3, 6 and 12 months of age. When expressed per 100 g body weight, food intake, pancreatic weight, and activities of trypsin, chymotrypsin and lipase were highest at 1 month and showed a similar decline with age in both obese and lean rats. In contrast, amylase activity declined only in the obese and remained elevated in the lean. Expressed per …