Journal article
Substance P activates Cl and K+ conductances in guinea-pig tracheal smooth muscle cells
Abstract
Substance P (SP) causes bronchoconstriction, but its effects on airway smooth muscle ion conductances are unknown. We investigated the effects of SP on single smooth muscle cells dissociated from guinea-pig trachealis. Under voltage clamp at -60 mV, SP evoked reversible contractions and inward current (ISP). ISP had a latency of approximately 1 s, reached a peak of 1039 +/- 147 pA (n = 19) about 2 s after onset of application, and declined to …
Authors
Janssen LJ; Sims SM
Journal
Canadian Journal of Physiology and Pharmacology, Vol. 72, No. 6, pp. 705–710
Publisher
Canadian Science Publishing
Publication Date
June 1, 1994
DOI
10.1139/y94-100
ISSN
0008-4212