Hepatitis B vaccination for reducing morbidity and mortality in persons with HIV infection

BACKGROUND: Hepatitis B vaccine has been recommended for use in people living with HIV (PLHIV) mostly because of the similarities in routes of infection and their prevalence in the same geographic areas. PLHIV may not develop sero-protection after receiving standard hepatitis B vaccine due to their compromised immune status. OBJECTIVES: To evaluate the efficacy of hepatitis B virus vaccine in PLHIV compared to placebo or no vaccine.