Five preference-based indexes in cataract and heart failure patients were not equally responsive to change Journal Articles uri icon

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  • OBJECTIVE: To compare the responsiveness to clinical change of five widely used preference-based health-related quality-of-life indexes in two longitudinal cohorts. STUDY DESIGN AND SETTING: Five generic instruments were simultaneously administered to 376 adults undergoing cataract surgery and 160 adults in heart failure management programs. Patients were assessed at baseline and reevaluated after 1 and 6 months. The measures were the Short Form (SF)-6D (based on responses scored from SF-36v2), Self-Administered Quality of Well-being Scale (QWB-SA), the EuroQol-5D developed by the EuroQol Group, the Health Utilities Indexes Mark 2 (HUI2) and Mark 3 (HUI3). Cataract patients completed the National Eye Institute Visual Functioning Questionnaire-25, and heart failure patients completed the Minnesota Living with Heart Failure Questionnaire. Responsiveness was estimated by the standardized response mean. RESULTS: For cataract patients, mean changes between baseline and 1-month follow-up for the generic indices ranged from 0.00 (SF-6D) to 0.052 (HUI3) and were statistically significant for all indexes except the SF-6D. For heart failure patients, only the SF-6D showed significant change from baseline to 1 month, whereas only the QWB-SA change was significant between 1 and 6 months. CONCLUSIONS: Preference-based methods for measuring health outcomes are not equally responsive to change.


  • Kaplan, Robert M
  • Tally, Steven
  • Hays, Ron D
  • Feeny, David
  • Ganiats, Theodore G
  • Palta, Mari
  • Fryback, Dennis G

publication date

  • May 2011

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