Journal article
Renin-angiotensin system blockade and cognitive function in patients at high risk of cardiovascular disease: analysis of data from the ONTARGET and TRANSCEND studies
Abstract
BACKGROUND: cardiovascular risk factors are associated with dementia and cognitive decline. We investigated the effects of renin-angiotensin system blockade on cognitive function in patients aged 55 years and older with established atherosclerotic cardiovascular disease or diabetes with end-organ damage in two clinical trials.
METHODS: in the main study, ONTARGET, a double-blind, double-dummy, randomised controlled trial, the effects on …
Authors
Anderson C; Teo K; Gao P; Arima H; Dans A; Unger T; Commerford P; Dyal L; Schumacher H; Pogue J
Journal
The Lancet Neurology, Vol. 10, No. 1, pp. 43–53
Publisher
Elsevier
Publication Date
1 2011
DOI
10.1016/s1474-4422(10)70250-7
ISSN
1474-4422
Associated Experts
Fields of Research (FoR)
Sustainable Development Goals (SDG)
Medical Subject Headings (MeSH)
AgedAged, 80 and overAngiotensin Receptor AntagonistsAngiotensin-Converting Enzyme InhibitorsBenzimidazolesBenzoatesCardiovascular DiseasesCognition DisordersDouble-Blind MethodDrug Therapy, CombinationFemaleFollow-Up StudiesHumansMaleMental Status ScheduleNeuropsychological TestsOdds RatioRamiprilRenin-Angiotensin SystemTelmisartanTreatment Outcome