Journal article
A Crossover Trial of Hospital-Wide Lactated Ringer’s Solution versus Normal Saline
Abstract
BACKGROUND: Whether lactated Ringer's solution is clinically superior to normal saline for routine intravenous administration of fluids is uncertain.
METHODS: In an open-label, two-period, two-sequence, cross-sectional, cluster-randomized, crossover trial, we assigned hospitals in Ontario, Canada, to use either lactated Ringer's solution or normal saline hospital-wide for a period of 12 weeks. After a washout period, hospitals switched to the …
Authors
McIntyre L; Fergusson D; McArdle T; English S; Cook DJ; Fox-Robichaud AE; Martin C; Marshall J; Pugliese M; Menon K
Journal
The New England Journal of Medicine, Vol. 393, No. 7, pp. 660–670
Publisher
Massachusetts Medical Society
Publication Date
August 14, 2025
DOI
10.1056/nejmoa2416761
ISSN
0028-4793