Journal article
Hydrolysis Products Generated by Lipoprotein Lipase and Endothelial Lipase Differentially Impact THP‐1 Macrophage Cell Signalling Pathways
Abstract
Macrophages express lipoprotein lipase (LPL) and endothelial lipase (EL) within atherosclerotic plaques; however, little is known about how lipoprotein hydrolysis products generated by these lipases might affect macrophage cell signalling pathways. We hypothesized that hydrolysis products affect macrophage cell signalling pathways associated with atherosclerosis. To test our hypothesis, we incubated differentiated THP-1 macrophages with …
Authors
Essaji Y; Yang Y; Albert CJ; Ford DA; Brown RJ
Journal
Lipids, Vol. 48, No. 8, pp. 769–778
Publisher
Wiley
Publication Date
8 2013
DOI
10.1007/s11745-013-3810-6
ISSN
0024-4201
Fields of Research (FoR)
Medical Subject Headings (MeSH)
Anaplastic Lymphoma KinaseCells, CulturedFatty AcidsGas Chromatography-Mass SpectrometryHumansHydrolysisLipaseLipoprotein LipaseLipoproteinsMacrophagesPhosphatidylcholinesPhosphorylationReceptor Protein-Tyrosine KinasesReceptors, Platelet-Derived Growth FactorSignal TransductionVascular Endothelial Growth Factor Receptor-2