Reference values for cross-linked C-telopeptide of type 1 collagen and pro-collagen type1 N-terminal propeptide in children and adolescents: Results from the Canadian Health Measures Survey

INTRODUCTION: Procollagen type 1 N-propeptide (P1NP) and carboxy-terminal telopeptide of type 1 collagen (CTX) are bone turnover markers for diagnosing and monitoring metabolic bone diseases and growth disorders. This study aimed to establish representative reference ranges for CTX and P1NP, as measured with an IDS-iSYS system, in Canadian children and adolescents. METHODS: Serum levels of CTX and P1NP were measured in participants of the …