Thrombosis is responsible for 1 in 4 deaths worldwide. Thrombosis, or intravascular clot formation, is the underlying driver of most cases of myocardial infarction, ischemic stroke, critical limb ischemia, deep vein thrombosis, and pulmonary embolism, disorders that are major causes of death and disability. Antithrombotic therapy, including antiplatelet agents, anticoagulants, and fibrinolytic drugs, are mainstays for the prevention or treatment of thrombosis. This chapter describes the mechanism of action, pharmacology, and indications for the antithrombotic drugs that are in current use, and identifies new agents in advanced stages of development.
Authors
Jaffer IH; Weitz JI
Book title
Hematology Basic Principles and Practice Eighth Edition