Journal article
Cortical α4β2-nicotinic acetylcholine receptors and cognitive decline in Parkinson's disease
Abstract
BackgroundAutopsy and in vivo molecular imaging studies suggest altered binding of the α4β2-nicotinic cholinergic receptor (α4β2-nAChR) with cognitive dysfunction in Parkinson's disease (PD).ObjectiveTo determine the relationship between cortical and hippocampal binding of the α4β2-nAChR with [18F]XTRA PET, a high-affinity radiotracer that enables quantification of α4β2-nAChR in these regions, and cognitive function in individuals with …
Authors
Mills KA; Kuwabara H; Du Y; Gomez G; Motley CS; Skorobogatova Y; Spiro E; Coughlin JM; Lesniak W; Brandt J
Journal
Journal of Parkinson’s Disease, Vol. 15, No. 2, pp. 374–386
Publisher
SAGE Publications
Publication Date
3 2025
DOI
10.1177/1877718x241313373
ISSN
1877-7171