Journal article
Structural insights into actin filament turnover
Abstract
The dynamic turnover of actin filaments drives the morphogenesis and migration of all eukaryotic cells. This review summarizes recent insights into the molecular mechanisms of actin polymerization and disassembly obtained through high-resolution structures of actin filament assemblies. We first describe how, upon polymerization, actin subunits age within the filament through changes in their associated adenine nucleotide. We then focus on the …
Authors
Oosterheert W; Boiero Sanders M; Bieling P; Raunser S
Journal
Trends in Cell Biology, Vol. 35, No. 10, pp. 893–906
Publisher
Elsevier
Publication Date
October 2025
DOI
10.1016/j.tcb.2024.12.009
ISSN
0962-8924