Journal article
Influence of Direct Oral Anticoagulant Levels and Thrombin Generation on Postoperative Bleeding [SONAR]: A Nested Case–Control Study
Abstract
A direct oral anticoagulant (DOAC) concentration threshold above which an impact on surgical hemostasis starts to occur is unknown. Thrombin generation assays (TGAs) provide a measure of the coagulation phenotype. This study aimed to determine whether preoperative TGA parameters are associated with postoperative bleeding, and whether this is partly due to residual DOAC levels.We conducted a nested case-control study using samples from …
Authors
Shaw JR; Li N; Grussé M; Van Dreden P; St John M; Nixon J; Spyropoulos AC; Schulman S; Levy JH; Carrier M
Journal
Thrombosis and Haemostasis, Vol. 125, No. 12, pp. 1226–1239
Publisher
Thieme
Publication Date
12 2025
DOI
10.1055/a-2521-0923
ISSN
0340-6245