PREGNANCY IN WOMEN WITH NOONAN SYNDROME

Background Noonan syndrome is similar phenotypically to Turner syndrome, accounting for one in 1000–2500 live births. Two thirds of patients have cardiac anomalies, half with pulmonary stenosis. Two cases of Noonan syndrome in pregnancy are presented, each woman with a different cardiac anomaly. Cases The first patient sought preconception counseling for pulmonary stenosis. She conceived within a year and had a cesarean because of prolonged rupture of membranes, transverse lie, and variable decelerations. The second patient presented at 14 weeks' gestation with an unrepaired coarctation of the aorta. She had an assisted vaginal delivery at 38 weeks. Conclusion Successful pregnancy was possible in women with Noonan syndrome. A coordinated multidisciplinary team approach improved the likelihood of a successful outcome.