Journal article
Nephroprotective Effects of Cilastatin in People at Risk of Acute Kidney Injury: A Systematic Review and Meta-analysis
Abstract
Rationale & Objective: Cilastatin is an inhibitor of drug metabolism in the proximal tubule that demonstrates nephroprotective effects in animals. It has been used in humans in combination with the antibiotic imipenem to block imipenem's renal metabolism. This systematic review and meta-analysis evaluated the nephroprotective effects of cilastatin in humans.
Study Design: Systematic review and meta-analysis of observational (comparative …
Authors
Acharya D; Ghanim F; Harrison TG; Scory TD; Shommu N; Ronksley PE; Elliott MJ; Collister D; Pannu N; James MT
Journal
Kidney Medicine, Vol. 6, No. 12,
Publisher
Elsevier
Publication Date
December 2024
DOI
10.1016/j.xkme.2024.100913
ISSN
2590-0595