Journal article
SECONDARY DRUG FAILURE OCCURRING DURING CHRONIC TREATMENT WITH LHRH: APPEARANCE OF AN ANTIBODY1
Abstract
Secondary drug failure with regard to subjective and hormonal responses occurred in a patient treated chronically with LHRH. This failure of response to hormone therapy was correlated with increased binding of 125I-LHRH by the patient's sera. Also, competitive displacement of 125I-LHRH by unlabelled LHRH was demonstrated. Affinity constants and titers of order appropriate for antibody were obtained. These data support strongly a report of …
Authors
Van Loon GR; Brown GM
Journal
The Journal of Clinical Endocrinology & Metabolism, Vol. 41, No. 3, pp. 640–643
Publisher
The Endocrine Society
Publication Date
September 1975
DOI
10.1210/jcem-41-3-640
ISSN
0021-972X