Experimental Evaluation of the Alpha-SPECT-Mini System with Machine-Learning-based Energy Reconstruction and Dynamic Windowing for In Vivo Imaging of Ac-225-labeled Radiopharmaceuticals

As one of the important multi-functional molecular imaging applications, the alpha-emitter radiopharmaceutical therapy attracts rising interest due to its great preclinical and clinical success. The Alpha-SPECT-mini system utilizes ultra-high energy resolution CdTe detectors to enable the ability to separate X- and gamma-rays emitted from the Ac-255 decay scheme. In vivo mice imaging studies with labeled Ac-225 injection has been demonstrated using Alpha-SPECT-mini. Energy peaks from Ac-225, Tl-209, Fr-221, Bi-213 can be used for tracing each element’s biological distribution. The Ac-225 washout processing and Bi-213 and Tl-209 accumulation in kidneys are observed during the In vivo mice imaging study.