Journal article
Plasma ghrelin and risks of sex-specific, site-specific, and early-onset colorectal cancer: A Mendelian randomization analysis
Abstract
BACKGROUND: Epidemiological and laboratory-based studies have provided conflicting evidence for a role of ghrelin in colorectal cancer development. We conducted two-sample Mendelian randomization (MR) analyses to evaluate evidence for an association of circulating ghrelin and colorectal cancer risk overall and by sex, cancer subsite, and age at diagnosis.
METHODS: Genetic instruments proxying plasma total ghrelin levels were obtained from a …
Authors
Hazelwood E; Manzano CL; Vincent EE; Albanes D; Bishop DT; Le Marchand L; Ulrich CM; Peters U; Murphy G; Samadder NJ
Journal
Cancer Epidemiology Biomarkers & Prevention, Vol. 33, No. 12, pp. 1727–1732
Publisher
American Association for Cancer Research (AACR)
Publication Date
December 2, 2024
DOI
10.1158/1055-9965.epi-24-0926
ISSN
1055-9965