Journal article
Clinical significance of periodic detection of hepatitis B virus YVDD mutation by ultrasensitive real-time amplification refractory mutation system quantitative PCR during lamivudine treatment in patients with chronic hepatitis B
Abstract
Monitoring hepatitis B virus (HBV) mutants periodically during nucleoside analogue treatment is of great clinical significance, particularly in persistently HBV DNA-positive patients. However, few studies have investigated the dynamic changes of HBV YMDD (Tyr-Met-Asp-Asp) and YVDD (Tyr-Val-Asp-Asp) populations in chronic hepatitis B (CHB) patients whilst undergoing lamivudine (LMV) treatment. In this study, we sought to investigate the dynamic …
Authors
Zeng Y; Yang B; Wu Y; Chen J; Shang H; Chen X; Su M; Wu S; Lin J; Ou Q
Journal
Journal of Medical Microbiology, Vol. 64, No. Pt_3, pp. 237–242
Publisher
Microbiology Society
Publication Date
March 1, 2015
DOI
10.1099/jmm.0.000022
ISSN
0022-2615