Journal article
Specification curve analysis to identify heterogeneity in risk factors for dementia: findings from the UK Biobank
Abstract
BackgroundIn 2020, the Lancet Commission identified 12 risk factors as priorities for prevention of dementia, and other studies identified APOE e4/e4 genotype and family history of Alzheimer’s disease strongly associated with dementia outcomes; however, it is unclear how robust these relationships are across dementia subtypes and analytic scenarios. Specification curve analysis (SCA) is a new tool to probe how plausible analytical scenarios …
Authors
Luo R; Zeraatkar D; Glymour M; Ellis RJ; Estiri H; Patel CJ
Journal
BMC Medicine, Vol. 22, No. 1,
Publisher
Springer Nature
DOI
10.1186/s12916-024-03424-w
ISSN
1741-7015