Journal article
TRSC-04 DE NOVO GTP SYNTHESIS IS A METABOLIC VULNERABILITY FOR THE INTERCEPTION OF BRAIN METASTASES
Abstract
Abstract
Patients with brain metastases (BM) face a 90% mortality rate within one year of diagnosis and the current standard of care is mainly palliative. Targeting BM-initiating cells (BMIC) is a feasible strategy to treat BM, but druggable targets are still very limited. Here, we applied Connectivity Map analysis to lung-, breast-, and melanoma- pre-metastatic BMIC gene expression signatures and identified inosine monophosphate dehydrogenase …
Authors
Kieliszek A; Mobilio D; Bassey-Archibong B; Johnson J; Piotrowski M; Aghaei N; Escudero L; Gwynne W; de Araujo E; Sedighi A
Journal
Neuro-Oncology Advances, Vol. 6, No. Supplement_1, pp. i40–i40
Publisher
Oxford University Press (OUP)
Publication Date
August 2, 2024
DOI
10.1093/noajnl/vdae090.132
ISSN
0801-3284