Alcohol-Related Seizure Disorders

Abstract This chapter describes the complex relationships between alcohol consumption and seizure disorders, which include alcohol withdrawal seizures and seizures that occur due to alcohol intoxication per se. We also present an update on the controversial but historically important concept of 'alcoholic epilepsy'. The current understanding of pathophysiological changes leading to alcohol withdrawal seizures is described in detail and illustrated by a typical case of excessive long-term alcohol consumption with multiple withdrawals and the associated medical and social sequelae. Potential causes and pathophysiological grounds for seizures due to alcohol intoxication are described in detail and a state-of-the-art understanding of the development of epilepsy in drinkers is presented. Special attention is paid to effects of alcohol consumption on existing seizure disorders. The differential diagnosis between different kinds of alcohol-related seizures and seizures in the context of epilepsy as well as appropriate management strategies are outlined.