Preprint
CircPVT1 sponges miR-33a-5p unleashing the c-MYC/GLS1 metabolic axis in breast cancer
Abstract
Abstract Altered metabolism is one of the cancer hallmarks. The role of circRNAs in cancer metabolism is still unexplored. Herein, we initially found that the expression of circPVT1 was significantly higher in tumoral tissues than in non-tumoral breast tissues. Basal like breast cancer patients with higher levels of circPVT1 exhibited shorter disease-free survival compared to those with lower expression. CircPVT1 ectopic expression rendered …
Authors
Palcau AC; Pulito C; De Pascale V; Casadei L; Valerio MC; Sacconi A; Rutigliano D; Donzelli S; Auciello RF; Pimpinelli F
DOI
10.1101/2024.06.04.597315
Preprint server
bioRxiv