Long-chain acylcarnitine 18:1 acutely increases human atrial myocardial contractility and arrhythmia susceptibility Journal Articles uri icon

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abstract

  • For the first time, the fatty acid metabolite, long-chain acylcarnitine 18:1, is shown to acutely increase the arrhythmia susceptibility and contractility of human atrial myocardium. In vitro, this was linked to an influx of Ca2+ and an enhanced propensity for spontaneous RyR2-mediated Ca2+ release.

authors

  • Aitken-Buck, Hamish M
  • Krause, Julia
  • van Hout, Isabelle
  • Davis, Philip J
  • Bunton, Richard W
  • Parry, Dominic
  • Williams, Michael JA
  • Coffey, Sean
  • Zeller, Tanja
  • Jones, Peter P
  • Lamberts, Regis R

publication date

  • July 1, 2021