Journal article
Long-chain acylcarnitine 18:1 acutely increases human atrial myocardial contractility and arrhythmia susceptibility
Abstract
Long-chain acylcarnitines (LCACs) are known to directly alter cardiac contractility and electrophysiology. However, the acute effect of LCACs on human cardiac function is unknown. We aimed to determine the effect of LCAC 18:1, which has been associated with cardiovascular disease, on the contractility and arrhythmia susceptibility of human atrial myocardium. Additionally, we aimed to assess how LCAC 18:1 alters Ca2+ influx and spontaneous Ca2+ …
Authors
Aitken-Buck HM; Krause J; van Hout I; Davis PJ; Bunton RW; Parry DJ; Williams MJA; Coffey S; Zeller T; Jones PP
Journal
AJP Heart and Circulatory Physiology, Vol. 321, No. 1, pp. h162–h174
Publisher
American Physiological Society
Publication Date
July 1, 2021
DOI
10.1152/ajpheart.00184.2021
ISSN
0363-6135