Journal article
Simplified molecular diagnosis of visceral leishmaniasis: Laboratory evaluation of miniature direct-on-blood PCR nucleic acid lateral flow immunoassay
Abstract
BACKGROUND: Diagnosis of visceral leishmaniasis (VL) in resource-limited endemic regions is currently based on serological testing with rK39 immunochromatographic tests (ICTs). However, rK39 ICT frequently has suboptimal diagnostic accuracy. Furthermore, treatment monitoring and detection of VL relapses is reliant on insensitive and highly invasive tissue aspirate microscopy. Miniature direct-on-blood PCR nucleic acid lateral flow immunoassay …
Authors
van Dijk NJ; Hagos DG; Huggins DM; Carrillo E; Ajala S; Chicharro C; Kiptanui D; Solana JC; Abner E; Wolday D
Journal
PLOS Neglected Tropical Diseases, Vol. 18, No. 5,
Publisher
Public Library of Science (PLoS)
DOI
10.1371/journal.pntd.0011637
ISSN
1935-2727