Variability in Brain Sodium Total Sodium Content (TSC) Mapping Quantification Methods

Throughout the literature, the methods of quantifying total sodium concentration (TSC) brain maps vary. Some studies use a two calibration phantom approach, some use a one calibration phantom approach, and some use anatomical references to quantify the TSC maps. This abstract investigates the variability of using one method versus another to see if a chosen method will inherently bias the resultant maps. It was found that no bias is provided by one method versus another as they provide no significant variance to the data.