Journal article
Molecular mechanism of actin filament elongation by formins
Abstract
Formins control the assembly of actin filaments (F-actin) that drive cell morphogenesis and motility in eukaryotes. However, their molecular interaction with F-actin and their mechanism of action remain unclear. In this work, we present high-resolution cryo-electron microscopy structures of F-actin barbed ends bound by three distinct formins, revealing a common asymmetric formin conformation imposed by the filament. Formation of new …
Authors
Oosterheert W; Boiero Sanders M; Funk J; Prumbaum D; Raunser S; Bieling P
Journal
Science, Vol. 384, No. 6692,
Publisher
American Association for the Advancement of Science (AAAS)
Publication Date
April 12, 2024
DOI
10.1126/science.adn9560
ISSN
0036-8075