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An AI-based approach for modeling the synergy...
Journal article

An AI-based approach for modeling the synergy between radiotherapy and immunotherapy

Abstract

Personalized, ultra-fractionated stereotactic adaptive radiotherapy (PULSAR) is designed to administer tumoricidal doses in a pulsed mode with extended intervals, spanning weeks or months. This approach leverages longer intervals to adapt the treatment plan based on tumor changes and enhance immune-modulated effects. In this investigation, we seek to elucidate the potential synergy between combined PULSAR and PD-L1 blockade immunotherapy using …

Authors

Peng H; Moore C; Zhang Y; Saha D; Jiang S; Timmerman R

Journal

Scientific Reports, Vol. 14, No. 1,

Publisher

Springer Nature

DOI

10.1038/s41598-024-58684-6

ISSN

2045-2322