Journal article
Neuromedin-U Mediates Rapid Activation of Airway Group 2 Innate Lymphoid Cells in Mild Asthma.
Abstract
Rationale: In asthma, sputum group 2 innate lymphoid cells (ILC2s) are activated within 7 hours after allergen challenge. Neuroimmune interactions mediate rapid host responses at mucosal interfaces. In murine models of asthma, lung ILC2s colocalize to sensory neuronal termini expressing the neuropeptide neuromedin U (NMU), which stimulates type 2 (T2) cytokine secretion by ILC2s, with additive effects to alarmins in vitro. Objectives: To …
Authors
Ju X; Nagashima A; Dvorkin-Gheva A; Wattie J; Howie K; Whetstone C; Ranjbar M; Cusack R; Ditta R; Paré G
Journal
American Journal of Respiratory and Critical Care Medicine, Vol. 210, No. 6, pp. 755–765
Publisher
American Thoracic Society
Publication Date
September 15, 2024
DOI
10.1164/rccm.202311-2164oc
ISSN
1073-449X