Journal article
Trimethylamine N-oxide impairs β-cell function and glucose tolerance
Abstract
Abstractβ-Cell dysfunction and β-cell loss are hallmarks of type 2 diabetes (T2D). Here, we found that trimethylamine N-oxide (TMAO) at a similar concentration to that found in diabetes could directly decrease glucose-stimulated insulin secretion (GSIS) in MIN6 cells and primary islets from mice or humans. Elevation of TMAO levels impairs GSIS, β-cell proportion, and glucose tolerance in male C57BL/6 J mice. TMAO inhibits calcium transients …
Authors
Kong L; Zhao Q; Jiang X; Hu J; Jiang Q; Sheng L; Peng X; Wang S; Chen Y; Wan Y
Journal
Nature Communications, Vol. 15, No. 1,
Publisher
Springer Nature
DOI
10.1038/s41467-024-46829-0
ISSN
2041-1723