Journal article
A176 RESTORATION OF IMPAIRED MICROBIOTA-MEDIATED ARYL HYDROCARBON RECEPTOR SIGNALING IN PATIENTS WITH CELIAC DISEASE BY ORAL TRYPTOPHAN SUPPLEMENTATION: AN EXPLORATORY STUDY
Abstract
AbstractBackground
Celiac disease (CeD) is an autoimmune condition driven by gluten in individuals expressing celiac-specific genes (HLA-DQ2 and/or DQ8). A strict gluten-free diet (GFD) is currently the only treatment. 30-40% of celiac patients exhibit persistent symptoms despite following a GFD ampersand:003E1 year and are considered non-responsive. Tryptophan is an essential amino acid metabolized by gut microbiota to produce indoles that …
Authors
Kirtikar U; Rueda GH; Szeto J; Galipeau H; Constante M; Wang X; Pinto-Sanchez M; Armstrong D; Bercik P; Verdu E
Journal
Journal of the Canadian Association of Gastroenterology, Vol. 7, No. Supplement_1, pp. 138–139
Publisher
Oxford University Press (OUP)
Publication Date
February 14, 2024
DOI
10.1093/jcag/gwad061.176
ISSN
2515-2084