Journal article
Human Fc gamma receptor IIIA blockade inhibits platelet destruction in a humanized murine model of ITP
Abstract
ABSTRACT: Fc gamma receptor (FcγR) IIIA is an important receptor for immunoglobulin G (IgG) and is involved in immune defense mechanisms as well as tissue destruction in some autoimmune diseases including immune thrombocytopenia (ITP). FcγRIIIA on macrophages can trigger phagocytosis of IgG-sensitized platelets, and prior pilot studies observed blockade of FcγRIIIA increased platelet counts in patients with ITP. Unfortunately, although blockade …
Authors
Gonzalez LG; Won KD; Tawhidi Z; Cummins E; Cruz-Leal Y; Cabado YT; Sachs UJ; Norris PAA; Shan Y; Bhakta V
Journal
Blood Advances, Vol. 8, No. 8, pp. 1869–1879
Publisher
American Society of Hematology
Publication Date
April 23, 2024
DOI
10.1182/bloodadvances.2023012155
ISSN
2473-9529