Design of Hydrated Porphyrin-Phospholipid Bilayers with Enhanced Magnetic Resonance Contrast Academic Article uri icon

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abstract

  • Computer simulations are used to design more hydrated bilayers, formed from amine-modified porphyrin-phospholipids (PoPs). Experiments confirm that the new constructs give rise to bilayers with greater water content. When chelated with manganese, amine-modified PoPs provide improved contrast for magnetic resonance and are safely used for imaging in vivo.

authors

  • Shao, Shuai
  • Do, Trang Nhu
  • Razi, Aida
  • Chitgupi, Upendra
  • Geng, Jumin
  • Alsop, Richard J
  • Dzikovski, Boris G
  • Rheinstadter, Maikel
  • Ortega, Joaquin
  • Karttunen, Mikko
  • Spernyak, Joseph A
  • Lovell, Jonathan F

publication date

  • January 2017

published in