Monoclonal Immunoglobulin Deposition Disease - a Review of Current and Emerging Data

Introduction Monoclonal immunoglobulin deposition disease (MIDD) is a rare complication of abnormal B and plasma cells, characterized by non-fibrillar, Congo-red negative deposits of monoclonal immunoglobulin molecules. These include light chain (LCDD), heavy chain (HCDD), or combined (LHCDD), and can involve several organs, most notably the kidney. Clone directed treatments for MIDD, including chemotherapy and autologous stem cell …