Drug susceptibility of Mycobacterium tuberculosis in HIV-infected and -uninfected Ethiopians and its impact on outcome after 24 months of follow-up. Journal Articles uri icon

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abstract

  • From a prospective cohort study on tuberculosis/human immunodeficiency virus (TB/HIV) interaction in Addis Ababa, Ethiopia, drug susceptibility results were available for 94 TB patients (46% HIV-infected). Resistance to one or more drug(s) was detected in 21 (22.3%) and multidrug resistance in five (5.3%) patients. Occurrence of resistance was not related to HIV status or outcome after 24 months of follow-up. However, among HIV-infected TB patients who died during follow-up, survival time in those with a resistant Mycobacterium tuberculosis strain was significantly shorter compared to those with a sensitive strain (6 vs. 13 months). Early detection of drug resistance and timely treatment change can therefore have a positive impact on survival in HIV-infected TB patients.

authors

  • Eyob, G
  • Guebrexabher, H
  • Lemma, E
  • Wolday, Dawit
  • Gebeyehu, M
  • Abate, G
  • Rigouts, L
  • van Soolingen, D
  • Fontanet, A
  • Sanders, E
  • Dorigo-Zetsma, JW

publication date

  • November 2004