Skin printer: Microfluidic approach for skin regeneration and wound dressings

We developed a microfluidics-based approach for the in-flow formation and in vivo application of cell-populated wound dressings, with the ability to reproduce key features of human skin. Human fibroblasts are incorporated within a continuously extruded biopolymer sheet with precise spatio-temporal control over the cell location and cell seeding density. The platform enables the continuous formation of cell-populated single-layer, bilayer, and vascularized sheets. The resulting wound dressings were implanted into murine wound models and the improved wound healing and keratinization were observed.