Journal article
Pembrolizumab plus chemotherapy versus chemotherapy in untreated advanced pleural mesothelioma in Canada, Italy, and France: a phase 3, open-label, randomised controlled trial
Abstract
BACKGROUND: Pleural mesothelioma usually presents at an advanced, incurable stage. Chemotherapy with platinum-pemetrexed is a standard treatment. We hypothesised that the addition of pembrolizumab to platinum-pemetrexed would improve overall survival in patients with pleural mesothelioma.
METHODS: We did this open-label, international, randomised phase 3 trial at 51 hospitals in Canada, Italy, and France. Eligible participants were aged 18 …
Authors
Chu Q; Perrone F; Greillier L; Tu W; Piccirillo MC; Grosso F; Lo Russo G; Florescu M; Mencoboni M; Morabito A
Journal
The Lancet, Vol. 402, No. 10419, pp. 2295–2306
Publisher
Elsevier
Publication Date
December 2023
DOI
10.1016/s0140-6736(23)01613-6
ISSN
0140-6736