A Multicenter, Randomized, Controlled Clinical Pilot Trial of the Feasibility of an Intensive RBC Transfusion Policy for Patients with Acute Leukemia Treated with Induction Chemotherapy or Stem Cell Transplant.

Abstract

Abstract Introduction: Patients with AML or ALL undergoing induction chemotherapy or SCT are at risk for hemorrhage. Hemoglobin (Hb) concentration may affect bleeding risk in thrombocytopenic patients. We performed a single-blinded pilot RCT to evaluate the feasibility of conducting a larger RCT to determine the effect of Hb on bleeding risk in thrombocytopenic patients. Objectives of the pilot RCT were: (1) to estimate the …