Journal article
Extracellular Matrix Injury of Kidney Allografts in Antibody-Mediated Rejection: A Proteomics Study
Abstract
BACKGROUND: Antibody-mediated rejection (AMR) accounts for >50% of kidney allograft loss. Donor-specific antibodies (DSA) against HLA and non-HLA antigens in the glomeruli and the tubulointerstitium cause AMR while inflammatory cytokines such as TNFα trigger graft injury. The mechanisms governing cell-specific injury in AMR remain unclear.
METHODS: Unbiased proteomic analysis of laser-captured and microdissected glomeruli and tubulointerstitium …
Authors
Clotet-Freixas S; McEvoy CM; Batruch I; Pastrello C; Kotlyar M; Van JAD; Arambewela M; Boshart A; Farkona S; Niu Y
Journal
Journal of the American Society of Nephrology, Vol. 31, No. 11, pp. 2705–2724
Publisher
Wolters Kluwer
Publication Date
November 2020
DOI
10.1681/asn.2020030286
ISSN
1046-6673
Fields of Research (FoR)
Medical Subject Headings (MeSH)
AdultAgedAllograftsAntibodiesBasement MembraneBiopsyCathepsinsCell LineCysteine EndopeptidasesExtracellular MatrixFemaleGalectin 1Gene ExpressionGlutathione TransferaseGraft RejectionHistocompatibility Antigens Class IHumansKidney GlomerulusKidney TransplantationKidney TubulesLamininMaleMatrix Metalloproteinase 2Matrix Metalloproteinase 3Membrane ProteinsMiddle AgedNecrosisProteomicsReceptor-Like Protein Tyrosine Phosphatases, Class 3Tumor Necrosis Factor-alpha