Preprint
The circulating proteome and brain health: Mendelian randomisation and cross-sectional analyses
Abstract
Decline in cognitive function is the most feared aspect of ageing. Poorer midlife cognitive function is associated with increased dementia and stroke risk. The mechanisms underlying variation in cognitive function are uncertain. Here, we assessed associations between 1160 proteins’ plasma levels and two measures of cognitive function, the digit symbol substitution test (DSST) and the Montreal Cognitive Assessment in 1198 PURE-MIND participants. …
Authors
Walker R; Chong M; Perrot N; Pigeyre M; Gadd D; Stolicyn A; Shi L; Whalley H; Nevado-Holgado A; McIntosh A
DOI
10.21203/rs.3.rs-3029765/v1
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