Journal article
Pharmacokinetic and Exposure Response Analysis of the Double-Blind Randomized Study of Posaconazole and Voriconazole for Treatment of Invasive Aspergillosis
Abstract
Background and ObjectiveA double-blind phase 3 study was conducted to compare posaconazole 300 mg intravenously (IV)/300 mg orally once daily (twice daily day 1) with voriconazole 4 mg/kg IV twice daily/200 mg orally twice daily (6 mg/kg day 1) for treatment of invasive aspergillosis. This analysis was conducted to summarize the pharmacokinetics and exposure–response relationships of posaconazole and voriconazole using plasma trough …
Authors
Maertens JA; Rahav G; Lee D-G; Haider S; Ramirez-Sanchez IC; Klimko N; Ponce-de-León A; Han S; Wrishko R; Winchell GA
Journal
Clinical Drug Investigation, Vol. 43, No. 9, pp. 681–690
Publisher
Springer Nature
Publication Date
September 2023
DOI
10.1007/s40261-023-01282-7
ISSN
1173-2563