Journal article
TNF is a critical cytokine in age-related dry eye disease
Abstract
Aging is a complex biological process that is characterized by low-grade inflammation, called inflammaging. Aging affects multiple organs including eye and lacrimal gland. Tumor necrosis factor (TNF) is a pleiotropic cytokine that participates in inflammation, activation of proteases such as cathepsin S, and formation of ectopic lymphoid organs. Using genetic and pharmacological approaches, we investigated the role of TNF in age-related dry eye …
Authors
Kelagere Y; Scholand KK; DeJong EN; Boyd AI; Yu Z; Astley RA; Callegan MC; Bowdish DM; Makarenkova HP; de Paiva CS
Journal
The Ocular Surface, Vol. 30, , pp. 119–128
Publisher
Elsevier
Publication Date
October 2023
DOI
10.1016/j.jtos.2023.08.004
ISSN
1542-0124