Vascular Mapping of the Human Hippocampus Using USPIO

In this work, we introduce the use of Ferumoxytol, an ultra-small superparamagnetic iron oxides (USPIO) agent, to increase the susceptibility in the veins and arteries to map the hippocampal microvasculature and to evaluate the fractional vascular density (FVD) in each of its subfields. We found that the hippocampal fissure, along with the fimbria, granular cell layer of the dentate gyrus and cornu ammonis layers (except for CA1), showed higher microvascular FVD than other parts of the hippocampus.