Detecting Residual Iron Contrast after Ferumoxytol Infusion in Cerebral Vasculature Using High-Resolution SWI at 7T

Ultra-small superparamagnetic iron oxides (USPIO) enhanced MRI has shown its great potential in detecting vascular abnormality in the brain on T2*-weighted sequences for better showing both macro- and micro-vasculature. In this study, we investigated the quantitative phase changes after Ferumoxytol infusion and examined its residual contrast in brain vasculature at 3-, 7- and 14-day follow-up SWI scans. To quantitatively measure the Ferumoxytol-induced susceptibility, the veins parallel to the main field were chosen for measurement. After measuring the intensity on high-pass filter phase images, the paired t-test showed a significant difference between pre-contrast and post-3d values from the follow-up visits.