Journal article
SYST-26 INVESTIGATING THE FUNCTIONAL ROLE OF GPNMB IN GLIOBLASTOMA AND THE TUMOR IMMUNE MICROENVIRONMENT AND ITS TARGETED ELIMINATION USING CAR-T CELLS
Abstract
AbstractINTRODUCTION METHODS
Glycoprotein nonmetastatic melanoma protein B (GPNMB) is active in the extracellular matrix of glioblastoma and presents a promising immunotherapy target for both tumor cells and immunosuppressive macrophages.
Immunohistochemistry was performed on patient derived xenograft (PDX) brains and tissue samples of 16 patient-matched primary/recurrent GBMs and 23 normal organ tissues. Whole cell proteomics was performed on 43 …
Authors
Savage N; Zemp F; Mikolajewicz N; Han H; Venugopal C; Tatari N; Chokshi C; Kislinger T; Mahoney D; Moffat J
Journal
Neuro-Oncology Advances, Vol. 5, No. Suppl 3, pp. iii33–iii33
Publisher
Oxford University Press (OUP)
Publication Date
August 4, 2023
DOI
10.1093/noajnl/vdad070.128
ISSN
0801-3284