Journal article
Somatic SF3B1 Mutation in Myelodysplasia with Ring Sideroblasts
Abstract
BACKGROUND: Myelodysplastic syndromes are a diverse and common group of chronic hematologic cancers. The identification of new genetic lesions could facilitate new diagnostic and therapeutic strategies.
METHODS: We used massively parallel sequencing technology to identify somatically acquired point mutations across all protein-coding exons in the genome in 9 patients with low-grade myelodysplasia. Targeted resequencing of the gene encoding RNA …
Authors
Papaemmanuil E; Cazzola M; Boultwood J; Malcovati L; Vyas P; Bowen D; Pellagatti A; Wainscoat JS; Hellstrom-Lindberg E; Gambacorti-Passerini C
Journal
The New England Journal of Medicine, Vol. 365, No. 15, pp. 1384–1395
Publisher
Massachusetts Medical Society
Publication Date
October 13, 2011
DOI
10.1056/nejmoa1103283
ISSN
0028-4793